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Current state for the development of metallopharmaceutics and anti-diabetic metal complexes

Furthermore, the excessive accumulation of ROS not only disrupts the process of melanin synthesis, but also destabilises, synthesises and disrupts the circulation of lipids in melanocytes, resulting in damage to the mitochondrial electron transport chain and increased ROS production, creating a vicious cycle and destroying melanocytes [19]

Glutathione redox balance in asthma: Effect of corticosteroids Because inhaled corticosteroids are the cornerstone of treatment for persistent asthma (3), clinical studies of GSH/GSSG redox balance in subjects with asthma are frequently confounded by corticosteroid exposure since both GSH and corticosteroids exert broad anti-inflammatory effects